The Bobcats, who led 4-3 after four innings, saw the Knights cross the plate six times in the top of the fifth to pull away for the 10-6 victory.
Colin Guilliams went 3-for-4 and was the winning pitcher for the Knights, as he hurled five innings, giving up four runs on nine hits, walking three and striking out four. Justin Stevers added three hits and an RBI, Mitchell and Jarrett White added two hits each.
James Williams led the Bobcats (2-3) with two hits, including a triple, and two RBIs. Hunter Marshall and Paul Parcell tallied two hits apiece.
Radford's Drew Cox, Nathan Jones, Anthony Miano and Hunter Marshall combined to give up 10 runs on 15 hits.
Photo: Radford second baseman Deion Baylor throws to first base for an out during Friday's game against the visitors from James River. (Photo by Bryant Altizer)